Spermidine is an important polyamine compound that occurs naturally in living organisms. It is widely distributed in plants, animals and microorganisms. Guanjie Biotech is a Spermidine supplier. Our spermidine is from wheat germ.100% pure plant. The quality of wheat germ extract spermidine is reliable. It plays a key role in cell growth, proliferation, differentiation and maintenance of normal cell function. As an important cellular regulator, spermidine not only participates in the process of cellular autophagy but also promotes cellular metabolic activities and inhibits cellular aging and decline, thus it has attracted much attention in the study of aging biology and health.
The concentration of spermidine in the human body gradually decreases with age. This phenomenon is thought to be closely related to the occurrence of aging-related diseases. It has been found that the decrease in the concentration of spermidine bulk powder with age leads to a gradual weakening of cell function. Therefore, to slow down the aging process, restoring the level of spermidine wheat germ extract has become one of the research hotspots in recent years.
Spermidine and the regulation of cellular function
Spermidine maintains intracellular homeostasis by binding to DNA, RNA, and proteins and regulates ribosome biosynthesis at the molecular level. Ribosomes are the core body of protein synthesis. Spermidine is involved in multiple steps of RNA transcription and modification during ribosome synthesis, ensuring efficient protein translation. In addition, wheat germ extract spermidine removes damaged organelles and protein aggregates by activating Autophagy. This improves cell regeneration and stress resistance. This mechanism is important for maintaining cell health and slowing down aging.
Spermidine and Aging
The concentration of spermidine in the body decreases as we age. This change is thought to be an important factor in the decline of cellular function during aging. Many studies have shown that declining levels of spermidine are closely related to phenomena such as cognitive decline, decreased immune function, and decline in the cardiovascular system in the elderly. To ameliorate these symptoms of aging, restoring spermidine levels in the body becomes a potential intervention strategy. The effects of spermidine on aging are mainly reflected in the following aspects.
• Delaying the onset of neurodegenerative diseases:
In experiments with fruit flies, researchers restored polyamine levels in the brains of aging fruit flies by feeding them food containing spermidine. This not only enhanced autophagy but also significantly suppressed aging-induced memory impairment. The study found that spermidine was able to improve learning and memory functions in aged fruit flies by increasing the repair capacity of nerve cells. This could delay the onset of neurodegenerative diseases.
• Antioxidant effects:
During aging, cells are susceptible to free radical damage. This is considered to be one of the important hallmarks of aging. Spermidine has significant antioxidant effects. It can slow down the damage to cells caused by oxidative stress, thus reducing diseases caused by aging. By improving the antioxidant capacity of cells, wheat germ extract spermidine plays an important role in slowing down aging and reducing the decline in organ function that occurs during the aging process.
• Improvement of cellular autophagy:
Autophagy is one of the important mechanisms for cells to maintain the stability of their internal environment. It promotes cellular health by removing damaged proteins, necrotic organelles, etc. from cells. Spermidine bulk powder enhances the self-repairing ability of cells by promoting the autophagy process. It plays an important role in anti-aging. Experiments have found that spermidine can increase the autophagic activity of cells, which in turn slows down the aging process.
• Enhance immune function:
With age, the immune system gradually declines, and the elderly are prone to infectious diseases. Spermidine has a role in enhancing the function of immune cells. Studies have shown that spermidine can enhance the function of T-cells and promote the health of the immune system, thus improving the body's immune response.
Research on Supplementation of Spermidine
With a deeper understanding of the biological function of bulk spermidine powder, scientists are beginning to explore the possibility of improving health through exogenous supplementation of spermidine.
• Effect of oral supplementation with spermidine:
In a groundbreaking study in 2009, Japanese scientists found that dietary supplementation with spermidine significantly increased blood levels of spermine in mice and humans. This finding suggests that exogenous supplementation of spermidine can effectively compensate for the lack of spermidine in the body. Further studies showed that mice and fruit flies fed spermidine not only restored normal levels of polyamines in their brains but also activated autophagy. This significantly inhibited the development of age-related memory impairment. The average lifespan of the fruit flies was extended as a result.
These results suggest that wheat germ extract spermidine has great potential in anti-aging and protecting neurological health. However, how to ensure the safety and tolerability of spermidine has become a key issue for further research by scientists.
•A study of spermidine on fruit flies:
It was found that by supplementing with spermidine, Drosophila's lifespan was extended and showed better health. Spermidine enhanced autophagy and delayed age-related memory impairment by restoring polyamine levels in Drosophila. This study provides an experimental basis for the application of spermidine in the field of anti-aging.
•Improvement of aging pathology by spermidine:
Supplementation with spermidine not only improves the physiological state of the elderly but also helps to alleviate, to some extent, various pathological changes caused by aging. For example, by restoring spermidine levels, it was found that cognitive ability was improved and cardiovascular health was enhanced in aged animals. The effects of wheat germ extract spermidine in delaying aging and preventing aging-related diseases are gradually being recognized.
Safety of Spermidine
Although spermidine has shown positive effects in slowing aging and improving health, research on its safety and tolerability remains a key issue .In 2018, researchers in Berlin, Germany, published a study on the safety and tolerability of spermidine supplements in older adults in the journal Aging. The study assessed the safety and tolerability of spermidine supplements in older adults through a randomized, placebo-controlled, double-blind Phase II clinical trial.
The study showed that bulk spermidine powder is safe and well-tolerated in older adults. The spermidine supplementation did not adversely affect the vital signs, body weight, clinical chemistry, and hematological safety parameters of the subjects. The results of this study provide a scientific basis for the clinical use of spermidine and its use as a potential anti-aging and health-improving supplement. Guanjie Biotech provides wholesale spermidine powder, and our wheat germ extract spermidine with 0.1%, 0.2%, and 0.5%. Feel free to inquire with us at info@gybiotech.com.
