Bulk Ergothioneine

Bulk Ergothioneine Supplier:

Guanjie Biotech provides high-quality bulk ergothioneine. We use fermentation and biosynthetic methods to produce ergothioneine bulk powder. The assay of our product can extend to more than 98%. We use the HPLC testing method. If you interested in our products or consult our ergothioneine price, we can provide you free sample and testing method. Welcome to enquiry us: info@gybiotech.com.  

 

COA:

Item	Specification	Analytical Method
Appearance	Off white to white fine powder	Visual
Identification	Positive	IR&1H NMR
Assay(On dried basis)	≥ 98.0%	HPLC
Loss on Drying	≤1.0%	USP
Residue on ignition	≤5.0%	USP
Heavy metals	≤ 10 ppm	ICP-MS
Arsenic	≤ 2 ppm	ICP-MS
Lead	≤1ppm	ICP-MS
Mercury	≤ 2 ppm	ICP-MS
Total bacteria count	≤10000 CFU/g	AOAC
Mold and Yeast	≤300 CFU/g	AOAC
Escherichia coli 10g	Absent/10g	AOAC
Staphylococcus aureus 10g	Absent/10g	AOAC
Salmonella 25g	Absent/25g	AOAC
Pseudomonas Aeruginosa 25g	Absent/25g	AOAC

 

Safety:

In healthy tissues, ergothioneine exerts antioxidant effects without interfering with ROS/RNS action. When oxidative damage becomes severe, ergothioneine accumulates in large amounts in body tissues and exerts antioxidant effects. Human studies suggest that ergothioneine may act primarily under conditions of oxidative stress. Ergothioneine is a powerful antioxidant. Compared to other natural antioxidants, bulk ergothioneine has the following advantages:

• Fast oral absorption. This allows for concentrated partitioning at sites sensitive to oxidative stress, slow metabolism, and long-lasting effects.

• It has high antioxidant activity in a physiological environment and does not promote Fenton reaction.

• Ergothioneine powder is not easily oxidized and has ideal thermal and pH stability.

• Ergothioneine bulk powder has good safety. It accumulates in high concentrations in tissues without observed toxicity.

Animal studies have shown that ERG also possesses other biological activities. It includes the potential to prevent UV-induced photodamage and melanosis caused by human skin. It can effectively protect chicks from glucocorticoid-induced cataract damage, and protects the liver, intestines, and kidneys.

In addition, bulk L-EGT aqueous solution has a good food preservation effect. Studies have shown that treatment of post-harvest Agaricus bisporus mushrooms with bulk ergothioneine solution slows down browning and extends shelf life. L-EGT aqueous solution extracted from enoki mushrooms can be used to inhibit the production of high iron hemoglobin in bigeye tuna meat and keep its color bright. Under low-temperature conditions, L-EGT-rich mushroom extracts inhibited lipid oxidation in salmon muscle tissues. In 2016, the European Union issued a safety declaration for L-EGT as a food additive, further broadening the way for the application of L-EGT powder in food preservation and freshness.

 

To date, no side effects have been identified in academic toxicology studies of ergothioneine bulk powder. Available evidence from population-based intervention studies of EGT suggests that EGT is an independent marker of lower risk of cardiometabolic disease and death. Increased intake of EGT-rich mushroom foods is positively associated with better cognitive function and lower odds of mild cognitive impairment. The unsafe use of EGT has not been reported.

 

Applications:

Ergothioneine as a natural amino acid with antioxidant properties. Bulk ergothioneine has a wide range of potential applications in the food industry. The following are the applications of ergothioneine powder in food additives:

● Functional health food

Ergothioneine has been added to a variety of functional health food products due to its antioxidant properties.In July 2017, the European Union published regulation 2017/1281, which approved ergothioneine as a new resource food ingredient. It also lists the specification criteria, heavy metal content, microbiological criteria, and use limits for addition to food.

● Dietary supplements

Ergothioneine is also used in dietary supplements. It can help human cell tissues with antioxidant, anti-inflammatory, inhibit heavy metal toxicity, protect the brain from neurotoxins, prevent cognitive decline, etc.

● General Foods

The EU expanded the use of ergothioneine in 2018. It can be applied in drinks, cereal bars, and other general food products in addition to dietary supplements.

● Cosmetic-grade ingredients

The application of bulk ergothioneine in cosmetics has been relatively mature. However, with the development of the market, as a "new generation" of functional ingredients, ergothioneine has been a more standardized development in the field of cosmetic applications.

● Food additives

Ergothioneine bulk powder can be used as a food additive to improve the nutritional value of food and extend shelf life. Its antioxidant properties help to protect food from oxidative damage and maintain the freshness and color of food.

 

Global Regulatory Status of Ergothioneine

1. United States

• In 2011, Oxis International Inc. announced that its pure L-ergothioneine, produced using a proprietary chemical synthesis method, had been recognized by an independent panel of scientific experts as having GRAS (generally recognized as safe) status. Bulk ergothioneine can be used and ingested as a food with an Acceptable Daily Intake (ADI) of 10.5mg/d. It was the only commercial company at the time producing dietary supplements using pure L-ergothioneine.

• Paris, France-based Tetrahedron announced in February 2015 that its ergothioneine products had passed an independent GRAS assessment.

• In 2018, the U.S. FDA certified the GRAS status of ergothioneine produced by Blue Califonia using genetically engineered bacteria for fermentation. It can be used in cakes, cookies and pastries (including granola bars), coffee, tea, fruit drinks and cider, carbonated soft drinks, and confectionery containing chocolate. It is used at a level of 5 mg/serving.

 

2. Europe.

• In 2016, EFSA adopted a Novel Food (NF) safety assessment for ergothioneine. This assessment concluded that synthetic bulk L-ergothioneine is safe for use in non-alcoholic beverages, cereal bars, milk, fresh dairy products and chocolate at a maximum of 5 mg per serving. The new food may be used as a dietary supplement. The daily dose should not exceed 30 mg/day for adults and 20 mg/day for children. The intended population is children over 3 years of age and adults in general, except pregnant and lactating women.

• In 2017 EFSA further confirmed that the estimated daily intake of ergothioneine corresponding to the previously approved additions is 2.82 mg/kg body weight (bw) for infants and 3.39 mg/kg bw for young children. Adults including pregnant and lactating women 1.31 mg/kg bw. At this additive level, synthetic bulk ergothioneine is safe.

• In 2018, the European Commission ((EU) 2018/462) approved synthetic L-ergothioneine for use in food. It can be added to non-alcoholic and milk beverages at 0.025g/kg, fresh milk products at 0.04g/kg, cereal bars at 0.2g/kg, chocolate confectionery at 0.25g/kg, and dietary supplements for people other than pregnant women and lactating mothers at 30mg/day, and for children aged 3 years and above at 20mg/day.

 

3. Other countries and regions

• A search for the term "ergothioneine" on the website of Health Canada yielded no results related to food additive regulations.

• A search for the term "ergothioneine" on the website of Food Standards Australia New Zealand (FSANZ) yielded no results related to regulation as a food additive.

• A search for "ergothioneine" on the websites of the Ministry of Health and the Ministry of Health and Welfare of Japan, the FDA of the Philippines, the Agri-Food and Veterinary Authority (AVA) of Singapore, and the FDA of Taiwan yielded no regulatory results for its use as a food additive.

 

Market:

Currently, bulk ergothioneine has realized cross-border development in cosmetic, food, functional food, and biopharmaceutical industries, etc. QY research research shows that the global ergothioneine market size will be about 130 million yuan in 2021, and is expected to reach 1.1 billion yuan in 2028, which shows that the development prospect is very promising. It is expected to reach 1.1 billion dollars in 2028. It can be seen that the development prospects are very broad.

Among them, cosmetics is one of the most widely used fields of bulk ergothioneine powder. The United States and Europe are the largest markets for EGT utilization. They regard EGT as the fifth-generation antioxidant, which is utilized in all kinds of big-brand cosmetics. In China, EGT has been listed in the catalog of cosmetic raw materials by the former State Food and Drug Administration since 2014, which has promoted the research and application of EGT by cosmetic companies.

 

Factory&Team：

 

Certification

 

Package & Shipment

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