Bulk Fisetin Powder

Bulk Fisetin Powder Supplier:

Bulk Fisetin Powder is light yellow in appearance. It is soluble in ethanol, acetone and acetic acid, but almost insoluble in water. And Guanjie Biotech extracts Bulk Fisetin Powder from the dried trunk of Sumac. We have focused on high-quality products. If you are interested in our products, we can provide you test report. Fisetin is a natural compound derived from plants with many benefits and is a member of the senolytics for its role in removing senescent cells. Welcome to enquire with us at info@gybiotech.com.

COA

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Cotinus coggygria Scop.	Conform	/
Part of the Plant	Branch	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Content	98%	98.12%	HPLC
Identification	Same spots as the reference	Conform	TLC
Organoleptic Data
Appearance	Powder	Conform	Visual
Color	Yellow	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Physical Characteristics
Particle Size	≥95(%) Pass 80Mesh	99.56	GB/T5507-2008
Loss on Drying	≤2(%)	1.18	GB5009.3
Total Ash	≤2(%)	0.76	CP2015
Bulk Density	40-60(g/100ml)	53.24	CP2015
Chemical Characteristics
Residual Solvent	EP4	Conform	Q/GJSW 0002S-2016
Pesticide Residue	EP4	Conform	CP2015
Heavy Metals(as Pb)	≤ 10(ppm)	Conform	USP<231>, method II
Arsenic (As)	≤ 2(ppm)	Conform	GB5009.11
Lead (Pb)	≤ 2(ppm)	Conform	GB5009.12
Cadmium(Cd)	≤ 0.5(ppm)	Conform	GB5009.15
Mercury(Hg)	≤ 0.5(ppm)	Conform	GB5009.17
Microbiological Tests
Total Plate Count	≤1000(cfu/g)	Conform	GB4789.2
Total Holothuroidea & Mold	≤100(cfu/g)	Conform	GB4789.15
E.Coli	Not Detected	Not Detected	GB4789.3
Salmonella	Not Detected	Not Detected	GB4789.4
Staphylococcus	Not Detected	Not Detected	CP2015

 

Chromatogram:

 

Where Does Fisetin Come From?

Lacin is found in a wide variety of plants, and the main sources include:

• Mullein (Rhus succedanea L):

This is a plant of the Lacertaceae family, and the extraction and refining process yields lacertinic acid. Plants such as Sumac, Lacerta, Saltbush, and Euphorbia: These plants contain Lacertin, which can be obtained through an extraction process.

And Guanjie Biotech extracts Bulk Fisetin Powder from the dried trunk of Sumac.

 

• Strawberries:

As a fruit, strawberries contain laccasein at a level of about 160 μg/g.

Laccasein from these plant sources can be obtained by different extraction methods. It is used in various fields such as the food industry, medicine and cosmetics. Due to its various biological activities such as antioxidant and anti•inflammatory properties, laccasein is gaining importance for its use in health and beauty products.

 

How Does Fisetin Produce?

•Pretreatment of sumac:

The collected raw materials of sumac were subjected to pretreatment steps such as washing, drying and crushing.

•Optimization of extraction process:

One-way examination and orthogonal test design method were used to determine the best combination of extraction solvent, time, pH and solvent amount.

• Crushing of Sumac raw materials

The dried sumac raw materials are crushed to a certain particle size, in order to increase the contact area between the solvent and the raw materials, and improve the extraction efficiency.

• Selection and optimization of solvent

Select ethanol as the extraction solvent, determine the optimal solvent concentration through single-factor investigation.

 

• Optimization of extraction conditions

Extraction time: determine the optimal extraction time by single-factor investigation.

pH value: adjust the pH value of the solvent to improve the solubility and extraction rate of laccase.

Solvent amount: Determine the appropriate amount of solvent to achieve the optimal balance of extraction efficiency and cost.

• Ultrasound-assisted extraction

Ultrasound-assisted extraction is used to further improve the extraction efficiency.

• Filtration and Concentration

The extract was filtered to remove solid impurities and then concentrated under reduced pressure to increase the concentration of Bulk Fisetin Powder.

• Resin adsorption and elution

Adsorption of fisetin in the extracted solution is carried out by using macroporous resin, and eluted by appropriate solvent.

 

•Purification and identification

The eluate is purified by column chromatography and other techniques to finally obtain high purity fisetin powder. The extracted lacin was identified and content determined by ultraviolet spectroscopy and high performance liquid chromatography (HPLC).

The optimal extraction process conditions were determined by orthogonal tests, including 65% ethanol concentration, pH 9, and 90 min per extraction for two times. Compared with the traditional extraction method, the optimized extraction process significantly increased the extraction rate of Bulk Fisetin Powder to 1.03%.

 

Research On Bulk Fisetin Powder

1. Molecular target studies

The multi•targeting properties of laccasein enable it to affect a wide range of signaling pathways both inside and outside the cell. The main molecular targets include:

• NF-κB: Lacertin inhibits the transcriptional activity of NF-κB by inhibiting the phosphorylation of IκB and blocking the entry of NF-κB into the nucleus.

• Nrf2: By activating Nrf2, Lacertin can promote the expression of antioxidant genes.

• STAT3: Lacosan can inhibit the phosphorylation of STAT3 and block its downstream signaling.

 

2. Metabolism and bioavailability

Lacertin is metabolized in the body mainly by reduction and glucuronidation in the liver. However, the low bioavailability of Bulk Fisetin Powder limits its clinical application:

• Absorption:

Lacin is poorly absorbed after oral administration and most of it is excreted from the body.

• Metabolism:

It is rapidly metabolized in the body to metabolites such as dihydrolaccasein and tetrahydrolaccasein.

Currently, the bioavailability of laccasein is improved by the following strategies:

• Chemical modification:

Through the synthesis of derivatives to enhance its water solubility and stability.

 

3. Experiments on anti-inflammatory effects

• In vitro experimental study

The anti-inflammatory effect of Bulk Fisetin Powder has been fully verified in in vitro experiments. For example, in the rat macrophage cell line RAW 264.7, lacosan significantly reduced lipopolysaccharide (LPS)-induced NO and PGE2 production. It also inhibited the expression of COX-2 and iNOS. This suggests that laccasein exerts its anti-inflammatory effects by inhibiting the production of inflammatory mediators.

• Animal model experiments

In a rat collagen-induced arthritis (CIA) model, lacosan significantly improved joint swelling and destruction. The experimental results suggest that it reduces the release of inflammatory factors by inhibiting the NF-κB and MAPK pathways, thus reducing the inflammatory response.

 

4. Antioxidant effect experiment

• Free radical scavenging experiment

Using the DPPH free radical scavenging assay, it can be observed that laccase has a significant free radical scavenging ability. The IC50 value in the experiment indicates that the antioxidant activity of lacinin even exceeds that of some traditional antioxidants.

• Cell experiments

In HepG2 hepatocellular carcinoma cells, using the oxidative stress model, the results showed that lacin was able to enhance the expression of intracellular antioxidant enzymes (e.g., SOD and GPx) by up-regulating the Nrf2 signaling pathway, thereby reducing the generation of ROS, and protecting cells from oxidative damage.

 

What Is Fisetin Market Trend?

The global Bulk Fisetin Powder market has shown a positive growth trend in recent years. This is mainly due to its wide range of applications in various fields such as pharmaceuticals, food additives, cosmetics, and nutraceuticals. The following is an analysis of the global laccasein market overview:

• Growth Trends:

The global smoke tree extract market is expected to grow to USD 490 million by 2029. This shows a steady compound annual growth rate (CAGR) of 6.4% (2023-2029). Moreover, the rapid growth of the global anti-aging market is expected to further expand the scope of the wholesale fisetin market. This is because of the potent anti-aging activity of Fisetin Bulk.

 

• Regional Market:

Asia Pacific, especially China market. It is expected to continue as a significant growth point for the global enkephalin market.

• Technological Development:

Natural nonsterones (laccasein) suffer from low yield and high cost. With the growth of market demand, synthetic methods such as biosynthesis and chemical synthesis are receiving extensive attention in the market, which is expected to drive further growth, of the market.

 

• Competitive Landscape:

The competitive landscape of the global laccasein market is gradually changing, and the competition between large multinational companies and regional brands is becoming more intense. A wide range of products containing laccasein ingredients are already available in the market.

The global Bulk Fisetin Powder market is experiencing positive growth, driven by technological advancements, increasing market demand, and emerging application areas. This market is expected to continue its growth momentum in the coming years.

 

Factory&Team：

 

Package & Shipment

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