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Bulk Urolithin A

Name: China Bulk Urolithin A Manufacturers Suppliers Factory - Buy Discount Bulk Urolithin A - Guanjie Biotech
Brand: Guanjie Biotech
SKU: 238779770

Purity:≧99.8%
Product Name: Urolithin A (UA)
CAS No.: 1143-70-0
Purity: ≥98.0% by HPLC
Appearance: Light yellow to off-white fine powder
Supply Ability: 50 Metric Tons / Year
Certifications: Halal,ISO9001,PAHS Free,NON-GMO,KOSHER,SC
Overseas warehouse(NJ,USA)
Provide Free Sample
MOQ: 1KG
Not for Private Person Sale

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Description

Urolithin A Bulk Powder: High-Purity Ingredient for Nutraceutical Formulations

Guanjie Biotech supplies high-purity Urolithin A bulk powder for nutraceutical and dietary supplement formulations. As a professional Urolithin A supplier and manufacturer, we independently produce Urolithin A powder using an insulation reaction process. Our Urolithin A 99.8% material is an off-white to yellow powder, providing a reliable Urolithin A raw material solution for global B2B customers. We can provide samples and testing reports. Welcome to contact us: info@gybiotech.com.

Urolithin A bulk powder

Why Choose Guanjie Biotech As Your Supplier?

Our Urolithin A powder is produced via an advanced enzymatic/synthetic bio-catalysis process that ensures high yield, structural stability, and minimal environmental impact.

● Raw Material Control: Strictly audited precursor compounds ensuring zero toxic residue.

● Precision Synthesis: Monitored biocatalytic/synthetic reactions to optimize isomer purity.

● Multi-Stage Purification: Recrystallization and chromatographic separation to achieve 98% purity.

● Testing & QA: Every batch undergoes full-spectrum analytical testing, including HPLC assay, LC-MS identity validation, and ICP-MS heavy metal profiling.

COA:

Items	Specification	Test Results	Method
Appearance	White to Light yellow powder	Light yellow powder	Visual
Identification	The spectrum corresponds to reference	Conforms	HNMR
Purity	NLT 98.0%	99.55%	HPLC
A single impurity	≤1.0%	0.45%	HPLC
Organic Solvent	≤3000ppm	N/D	GC
Heavy Metals
Pb	≤0.5 ppm	Conform	GB5009
Hg	≤0.5 ppm	Conform	GB5009
Cd	≤0.5 ppm	Conform	GB5009
As	≤0.5 ppm	Conform	GB5009
Total Microbial Count	≤500CFU/g	＜10	GB4789
Coliform	≤0.92MPN/g	Conform	GB4789
Mold and yeast	≤50CFU/g	Conform	GB4789
Staphylococcus aureus	0/25g	Conform	GB4789
Salmonella	0/25g	Conform	GB4789
Solubility	Soluble in DMSO, slightly soluble in methanol, ethanol
Conclusion	All inspection items are in conformity with the specifications.
Packing	Sealed export grade drum & double of sealed plastic bag.
Storage	Store in cool and dry place, keep away from strong light and heat.

What Is Urolithin A?

Urolithin A CAS Number (1143-70-0) is also known as 3,8-dihydroxy-6H-dibenzo[B,D]pyran-6-one. It is a natural metabolite found in pomegranates and some other fruits and nuts. Urolithin A is not found in food. It is produced by intestinal flora and is a natural metabolite present in ellagitannins. Urolithin A bulk powder is soluble in organic solvents. Such as dimethyl sulfoxide and N, N-dimethylformamide. Bulk Urolithin A powder is slightly soluble in water.

Urolithin A Test

The morphology of bulk Urolithin A powder liposomes was evaluated using atomic force microscopy (AFM). The results showed that individual Urolithin A liposomes exhibited predominantly spherical or ellipsoidal structures within the scanning range, with a relatively uniform particle distribution. The average particle size was approximately 90 nm, consistent with laser nanoparticle sizing results. These findings indicate successful formation of stable nanometer-scale liposomal Urolithin A, supporting its potential application in advanced Urolithin A formulation and liposomal nutraceutical delivery systems.

What is the Alkali stability of urolithin A?

The pH-dependent solubility of hydrophobic polyphenols provides a basis for using a pH-driven loading method in Urolithin A encapsulation. However, evaluating Urolithin A stability under alkaline conditions is essential before formulating liposomal Urolithin A. Experimental results showed that bulk Urolithin A powder exposed briefly to strongly alkaline conditions and subsequently returned to neutral pH maintained its structure and content. These findings support the feasibility of this formulation approach. During processing, the alkaline Urolithin A solution should be prepared immediately before use, and neutralization should be completed within 10 minutes.

In vitro acceptability and bioavailability of urolithin A liposomes:

An in vitro simulated-digestion model was used to evaluate the bioaccessibility of Urolithin A powder and liposomal Urolithin A prepared at different soy lecithin concentrations. Unencapsulated Urolithin A showed 25.9% bioaccessibility after simulated gastrointestinal digestion. Liposomal formulations achieved conversion rates of 29.6%, 29.8%, 61.3%, and 79.6% as soy lecithin concentration increased. The formulation containing 20 mg/mL soy lecithin improved Urolithin A bioaccessibility by 2.07-fold. These results indicate that optimized phospholipid concentrations can significantly improve Urolithin A bioavailability and support advanced Urolithin A formulation development for nutraceutical applications.

Urolithin A Formulations

Capsules and Hard Tablets

Bulk Urolithin A Powder is well suited to solid dosage forms such as capsules and hard tablets. Its powder format allows manufacturers to combine Urolithin A with appropriate fillers, binders, and other functional ingredients during formulation. Urolithin A capsules are particularly convenient for precise dosing and scalable production, while tablets can accommodate multi-ingredient formulations. For supplement manufacturers, formulation design should consider dosage uniformity, powder flowability, excipient compatibility, and the target specification of Urolithin A 98% or 99%.

Bulk Urolithin A Anti-aging

Softgels and Liposomal Formulations

Urolithin A powder formulation can also be considered for advanced delivery formats, including softgels and lipid-based formulations. When developing a Urolithin A liposomal formulation, manufacturers need to evaluate its physicochemical properties, lipid composition, encapsulation performance, and processing conditions. These parameters can influence dispersion, stability, and final product quality. Softgel formulations may be suitable for supplement brands developing premium Urolithin A nutraceuticals, particularly when combining Urolithin A with other lipid-compatible ingredients.

Urolithin A + NMN or NAD+ Boosters

Combining Urolithin A and NMN provides an opportunity to develop formulations targeting complementary aspects of cellular and mitochondrial health. Urolithin A is commonly associated with mitophagy, while NMN and other NAD+ precursor ingredients are used in formulations designed to support NAD+ metabolism. This combination can therefore be considered for advanced anti-aging supplement concepts focused on mitochondrial quality and cellular energy metabolism.

Urolithin A + Resveratrol or PQQ

Urolithin A and Resveratrol or PQQ can be combined in mitochondrial health formulations that target complementary biological pathways. Urolithin A is associated with mitochondrial quality-control processes, while resveratrol and PQQ are commonly incorporated into antioxidant and mitochondrial-support formulas. For product developers, this combination may provide a broader positioning strategy for mitochondrial health supplements, although formulation claims should always be supported by appropriate scientific and regulatory evidence.

Urolithin A + CoQ10 and Spermidine

A combination of Urolithin A, CoQ10, and Spermidine can be used to create a multi-ingredient nutraceutical formula addressing several aspects of cellular and mitochondrial health. CoQ10 is widely used in energy-metabolism formulations, while spermidine is commonly associated with autophagy-related research. Together with Urolithin A, these ingredients can support the development of premium anti-aging and healthy-aging supplements, provided that dosage, stability, compatibility, and regulatory requirements are carefully evaluated during product development.

What is the recommended dose?

When considering bulk Urolithin A powder supplements, it is important to remember that these dietary products are not regulated by the FDA. Although there is no recommended dosage, bulk Urolithin A powder is available for purchase in a variety of dosages. These include at least the following doses: 500 mg, 700 mg, 800 mg, 1,000 mg, and 2,000 mg.

What are the possible side effects?

Although the study sample size was small, careful investigation of additional information on adverse events suggests that there may be a dose-response relationship for headache.

Research progress:

• The existence of urolithin A was first discovered by a team of scientists in 2005.

• In 2016, an article published in a post linked urolithin A to aging for the first time. The article showed that UA not only extends the lifespan of nematodes but also enhances muscle function in mice.

• Already in 2018 UA was designated as a "generally recognized as safe" edible substance. It can be added to protein shakes, meal replacement drinks, instant oatmeal, nutritional protein bars and milk beverages (up to 500 mg/serving), Greek yogurt, high-protein yogurt and milk protein shakes (up to 1000 mg/serving).

Urolithin A bulk powder

• In October 2023, urolithin A was filed as a new cosmetic ingredient. The filing number is "Guozhengyuan Beiqi 20230036". The filing was made by the Swiss company Amasentis. The purpose of bulk Urolithin A powder is as an anti-wrinkle agent, which can be used in skin care cosmetics except spray products.

FAQ

Q1: What is the minimum order quantity (MOQ) for wholesale Urolithin A powder?

A: Our standard MOQ is 1 kg of bulk Urolithin A raw material for testing and evaluation purposes. We also provide small sample batches (100g–500g) upon request for qualified buyers and formulation R&D.

Q2: What testing methods do you use to verify Urolithin A purity?

A: We utilize High-Performance Liquid Chromatography (HPLC) to verify purity (Urolithin A 98.0%). Each batch is accompanied by an HPLC spectrum report, LC-MS identity confirmation, and an independent third-party COA.

Q3: How does Urolithin A differ from Pomegranate Extract?

A: Pomegranate extract contains ellagitannins, which depend on specific gut bacteria to convert into Urolithin A. More than 60% of people lack the necessary microbiome to perform this conversion efficiently. Pure Bulk Urolithin A ingredient provides a direct, biologically active dose regardless of individual gut flora differences.

Q4: Is your Urolithin A powder compliant with dietary supplement regulations?

A: Yes. Our Urolithin A production process conforms to cGMP and ISO standards, ensuring our Urolithin A meets strict heavy metal, pesticide, and microbial specifications for market entry in North America, Europe, and Asia.

Q5: Can urolithin A support joint health?

One of the most common challenges of aging is joint pain. There is some evidence that High-purity Urolithin A powder may help reduce tissue damage and joint pain.

Q6: What About Urolithin A?

Clinical trials are small and short, so safety data are very limited. It is best to start with a low-dose bulk Urolithin A powder and track any adverse effects.