Bulk Urolithin A

Bulk Urolithin A Powder Supplier

Guanjie Biotech provides bulk Urolithin A powder. As a professional Urolithin A supplier in plant extract industry, we use insulation reaction to produce UA powder independently. It is off white to yellow powder and the purity of Urolithin A is ≧ 99.8%. We can provide samples and testing reports. Welcome to contact us: info@gybiotech.com.

COA:

Items	Specification	Test Results	Method
Appearance	White to Light yellow powder	Light yellow powder	Visual
Identification	The spectrum corresponds to reference	Conforms	HNMR
Purity	NLT 98.0%	99.55%	HPLC
A single impurity	≤1.0%	0.45%	HPLC
Organic Solvent	≤3000ppm	N/D	GC
Heavy Metals
Pb	≤0.5 ppm	Conform	GB5009
Hg	≤0.5 ppm	Conform	GB5009
Cd	≤0.5 ppm	Conform	GB5009
As	≤0.5 ppm	Conform	GB5009
Total Microbial Count	≤500CFU/g	＜10	GB4789
Coliform	≤0.92MPN/g	Conform	GB4789
Mold and yeast	≤50CFU/g	Conform	GB4789
Staphylococcus aureus	0/25g	Conform	GB4789
Salmonella	0/25g	Conform	GB4789
Solubility	Soluble in DMSO, slightly soluble in methanol, ethanol
Conclusion	All inspection items are in conformity with the specifications.
Packing	Sealed export grade drum & double of sealed plastic bag.
Storage	Store in cool and dry place, keep away from strong light and heat.

 

What Is Urolithin A?

Urolithin A is also known as 3,8-dihydroxy-6H-dibenzo[B,D]pyran-6-one. It is a natural metabolite found in pomegranates and some other fruits and nuts. Urolithin A is not found in food. It is produced by intestinal flora and is a natural metabolite present in ellagitannins. Urolithin A bulk powder is soluble in organic solvents. Such as dimethyl sulfoxide, N,N-dimethylformamide. And bulk Urolithin A powder is slightly soluble in water.

 

Urolithin A Test 

 

The appearance of bulk Urolithin A powder liposomes was visualized by AFM, and it can be observed that the single vesicles were in spherical or ellipsoidal structure within the scanning range. Moreover, the distribution is more uniform, and the average particle size of urolithin A liposomes is around 90 nm. This is consistent with the results determined by laser nanoparticle sizing.

 

What is the Alkali stability of urolithin A?

The property that the water solubility of polyphenols changes with pH is the basic condition for the pH-driven method to embed hydrophobic polyphenols. However, polyphenols are prone to degradation in an alkaline environment, so the investigation of the stability of bulk Urolithin A powder under alkaline conditions is an important prerequisite for the embedding by the pH-driven method. The results showed that the recovery of urolithin A from strongly alkaline conditions to neutral conditions within a certain period of time did not have a significant effect on its structure and content. This can verify the feasibility of the pH-driven method for the embedding of urolithin A. Therefore, in the experiment, the urolithin A alkaline solution was prepared in a ready-to-use manner, and the time for mixing the liposomes with the urolithin A mother liquor and adjusting the pH back to neutral was controlled within 10 min.

 

In vitro acceptability and bioavailability of urolithin A liposomes:

We used an in vitro simulated digestion model to investigate the conversion rate and bioavailability of urolithin A liposomes prepared with different soy lecithin concentrations during digestion. The bioaccessibility of unembedded bulk Urolithin A powder after gastrointestinal simulated digestion was 25.9%. The conversion rates of urolithin A liposomes were 29.6%, 29.8%, 61.3% and 79.6% with increasing soy lecithin concentration. The bioaccessibility of urolithin A after embedding were all increased compared to unembedded. Among them, the liposome with soy lecithin of 20 mg/mL increased the bioacceptability of urolithin A by 2.07-fold. This indicates that the higher the soy lecithin concentration, the higher the bioacceptability of the prepared liposome of urolithin A.

 

Why is Bulk Urolithin A Anti-aging?

Recent research has found that when urolithin A was added as a dietary supplement, it not only activated the lymphoid region of the immune system in mice, but also enhanced the overall performance of hematopoietic stem cells. This shows the potential of bulk Urolithin A powder to combat age-related immune system decline.

 

The team explained that mitochondrial abnormalities have been identified as a contributing factor in the aging of hematopoietic stem cells. Urocitin A acts as a mitochondrial modulator, effectively restoring the function of mitochondria within hematopoietic stem cells.

 

What is the recommended dose?

When considering bulk Urolithin A powder supplements, it is important to remember that these dietary products are not regulated by the safety department. Although there is no recommended dosage, bulk Urolithin A powder is available for purchase in a variety of dosages. These include at least the following doses: 500 mg, 700 mg, 800 mg, 1,000 mg, and 2,000 mg.

 

What are the possible side effects?

Although the study sample size was small, careful investigation of additional information on adverse events suggests that there may be a dose-response relationship for headache.

 

Research progress:

• The existence of urolithin A was first discovered by a team of scientists in 2005.

• In 2016, an article published in post linked urolithin A to aging for the first time. The article showed that UA not only extends the lifespan of nematodes but also enhances muscle function in mice.

• Already in 2018 UA was designated as a "generally recognized as safe" edible substance. It can be added to protein shakes, meal replacement drinks, instant oatmeal, nutritional protein bars and milk beverages (up to 500 mg/serving), Greek yogurt, high-protein yogurt and milk protein shakes (up to 1000 mg/serving).

• In October 2023, urolithin A was filed as a new cosmetic ingredient. The filing number is "Guozhengyuan Beiqi 20230036". The filing was made by the Swiss company Amasentis. The purpose of bulk Urolithin A powder is anti-wrinkle agent, which can be used in skin care cosmetics except spray products.

 

FAQ

• Who would benefit the most from urolithin A?

According to clinical trials, bulk Urolithin A powder supplementation in middle-aged and older adults may increase muscle strength and endurance.

• Should athletes take urolithin A?

Clinical trials are currently being conducted on middle-aged and older adults. There is little information on the effects of this supplement on athletes.

• Can urolithin A support joint health?

One of the most common challenges of aging is joint pain. There is some evidence that urolithin A may help reduce tissue damage and joint pain.

• What About urolithin A?

Clinical trials are small and short, so safety data are very limited. It is best to start with a bulk Urolithin A powder low dose and track any adverse effects.

• Is it possible to be an elite strength athlete without supplementation?

Yes, many elite Hercules and strength athletes avoid bulk UA powder supplements and prefer pure nature.

 

Factory&Team：

 

Certification

 

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