Ergothioneine powder (EGT) is a naturally occurring amino acid first isolated from the ergot fungus in 1909 by the French pharmacist Charles Tanret and named after the fungus. However, it cannot be synthesized by the body itself and can only be obtained through the diet, with mushrooms being the main dietary source.
The antioxidant effects:
(1) It has the ability to prevent the generation of OH and other free radicals as well as directly scavenge reactive oxygen species (ROS) such as hypochlorous acid and peroxynitrite.
2) It can effectively chelate a variety of divalent metal cations;
3) It can interact with other natural antioxidant defense systems in the body. Examples include activation of intracellular antioxidant pathways involving MAPKs and regulation of peroxidase and antioxidant enzyme levels;
4）Inhibits oxidation of various hemoglobins.
What Are The Advantages Of Ergothioneine Powder?
1) It is an adaptive antioxidant. It will preferentially accumulate in cells and tissues exposed to oxidative stress and damage. The organic cation transporter protein OCTN1 (now known as SLC22A4, a 551 amino acid transporter protein with three glycosylation sites) in the human body transports ergothioneine to the desired site;
2) The human body has a regenerative cycling pathway for ergothioneine. Binding of ergothioneine to glutathione can regenerate it so that it can cycle and react with single-linear oxygen to achieve a more comprehensive and long-lasting antioxidant effect;
3) Ergothioneine is excreted very slowly in the body, thus ergothioneine can be highly retained in the body tissues and red blood cells of humans and other animals to fully utilize its effects. It exists mainly in the form of thione and has ideal thermal and pH stability.
The potential mechanisms of action of ergothioneine on neurodegenerative diseases are multifaceted:
1) Ergothioneine can directly inhibit the accumulation of bacteria and Aβ in the hippocampus and lipid peroxidation in neuronal cells;
2) It can affect other antioxidants. Examples include maintaining the GSH/GSSG ratio and superoxide dismutase activity and restoring acetylcholinesterase activity in the brain;
3) It prevents the formation of peroxynitrite.
4) It can directly reduce ROS levels and inhibit the transcriptional pathway of NF-κB.
What Are The Functions Of Ergothioneine powder On Skin Care?
Due to its special antioxidant ability, ergothioneine has become a high-potential anti-aging ingredient in the skin care industry. In the "2022 Potential Ingredient List", ergothioneine is ranked as the ninth potential ingredient. In addition, the beauty repair big data statistics major anti-aging ingredients in anti-aging skin care products filed growth rate, ergothioneine with 64.2% growth rate ranked eighth.
The skin care of ergothioneine is mainly reflected in anti-aging, and its mechanism of action has the following 5 main points:
1) Anti-photo-aging. It can mainly anti-ultraviolet (UV), inhibit UV-induced peroxidation, inflammatory factors/β-Gel, MMPs expression.
2) Antioxidant. Prevents oxidative damage, repairs DNA damage, inhibits the onset of apoptosis, and increases cell viability;
3) Anti-glycation, reducing the generation of AGEs;
4) Prevention of mitochondrial membrane potential and tDNA damage;
5) prevention of telomere damage, activation of telomerase activity and reduction of telomere shortening rate.
In addition, ergothioneine has been shown to be useful in eye protection, improving cardiovascular health and muscle repair.
Synthetic Biology Of Ergothioneine Powder
Ergothioneine can be obtained in three ways: mushroom extraction, chemical synthesis and synthetic biology.
Mushroom extraction has been abandoned due to its low content and high cost.
Chemical synthesis is prone to chiral isomer impurities and solvent residues, which are costly and have an impact on the environment.
Currently, ergothioneine is mainly prepared by synthetic biology fermentation.
With the rapid development of synthetic biology, the cost of ergothioneine will continue to decrease. When ergothioneine becomes "affordable" and regulatory restrictions are broken through, ergothioneine may become as popular an ingredient as sodium hyaluronate in the future.
We are proud to offer our expertise in processing natural bulk ergothioneine powder with the utmost efficiency. Our advanced resources and capabilities enable us to handle a diverse range of requirements with precision. We warmly welcome inquiries and negotiations from all interested parties looking to incorporate ergothioneine into their products or research. For further information and communication, please do not hesitate to reach out to us at info@gybiotech.com. Our team is ready to assist you and provide the necessary guidance to meet your specific needs.
