Luteolin powder is widely distributed in nature and is named after the leaves, stems and branches of the herb Lignan, originally isolated from the genus Lignan, family Lignanaceae, and can be isolated from a variety of natural herbs and vegetables and fruits. So what effects does Luteolin have?
●Anti-aging
Luteolin powder is a flavonoid abundant in the human diet, as mentioned in the paper The Evaluation of Geroprotective Effects of Selected Flavonoids in Drosophila melanogaster and Caenorhabditis elegans. "Flavonoids are a group of well-studied natural compounds with antioxidant, antitumor, antihyperglycemic, cardioprotective, and neuroprotective properties."
The paper found that it prolongs the lifespan and has potential anti-aging effects in Cryptobacterium hidradenum and female Drosophila melanogaster.
●Neuroprotection
Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice This paper mentions, "The flavonoid luteolin reduces neuroinflammation and improves learning and memory in aged mice. "
The paper also found that a diet supplemented with lignans suppressed neuroinflammation by inhibiting microglia activity during aging and LPS activation in adults.
The neuroprotective effects of luteolin also include the suppression of fear, anxiety, and depression in rats with post-traumatic stress disorder. In this study, lignocaine administration restored increased norepinephrine and reduced serotonin levels in the fear circuit, medial prefrontal cortex, and hippocampal structures in rats exposed to chronic stress and showed antidepressant and anxiolytic effects.
In addition, lignocaine has the potential to improve brain fog in post-neoconiosis. Symptoms of long-term-COVID syndrome, particularly brain fog, are similar to those experienced by patients receiving chemotherapy for cancer and those suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS).
The pathogenesis of brain fog in these disorders is currently unknown, but may involve neuroinflammation in which mast cells are stimulated by pathogens and stress to release mediators that activate microglia and lead to hypothalamic inflammation. These processes can be alleviated by phytosomal preparations of the natural flavonoid lignocaine (in olive pomace oil).
●Antiviral
The interaction between the receptor-binding domain (RBD) of SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) is critical for virus entry and subsequent replication.
A study found that lignocaine exhibits strong metastable effects when bound to a previously unrecognized distal binding site of the RBD domain away from the interface of RBD and ACE2, which could be a potential target for future drug discovery.
In addition, the RNA-dependent RNA polymerase (RdRp) in the SARS-CoV-2 viral protein is responsible for viral genome replication and has emerged as one of the most promising targets for drug intervention against SARS-CoV-2.
The paper Quercetin and Luteolin powder are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase found that lignocaine and quercetin have the ability to inhibit the RdRp enzyme. The IC 50 for inhibition of SARS-CoV-2 RdRp was 4.6 ± 0.3 µM for lignocaine and 6.9 ± 1.0 µM for quercetin.
● Delay of gonadal senescence
Improvement of Testicular Steroidogenesis Using Flavonoids and Isoflavonoids for Prevention of Late-Onset Male Hypogonadism. This study noted that flavonoids and isoflavonoids, such as apigenin, apigenin, lignan, and luciferin apigenin, lignan, quercetin and xanthinogen, are effective in delaying the onset of late-onset hypogonadism associated with male aging. Lignans cause an increase in progesterone and testosterone synthesis in LC540 mesenchymal cells by activating StAR expression and leading to increased progesterone and testosterone synthesis in LC540.
Guan jie focuses on luteolin powder researching, producing and sale. Our source is main from bud and peanut shells. We have our own two factories. They cover an area of 7000㎡, including GMP standard workshop of 2000㎡. All of which are fully compliant with good manufacturing policies and follow the strictest quality controls. We can provide you with high quality products at the best price. If you interested in our products, please feel free to contact us:info@gybiotech.com
