Ergothioneine bulk powder is a natural amino acid derivative produced by bacteria and fungi. It has powerful antioxidant and anti-inflammatory properties. In recent years, with in-depth research on skin aging mechanisms and anti-aging ingredients, ergothioneine has attracted widespread attention in the cosmetic industry.

Biological properties of ergothioneine
1 Chemical structure and source
The chemical structure of ergothioneine is 2-thio-histidine. Its unique structure gives it a powerful antioxidant ability. Ergothioneine is mainly synthesised in nature by certain bacteria and fungi. It is passed through the food chain to humans and animals. Mushroom foods such as enoki mushrooms and almond mushrooms are one of the important sources of ergothioneine.

2 Antioxidant and anti-inflammatory properties
Ergothioneine acts as a potent antioxidant. It neutralises free radicals and protects cells from oxidative damage. Its anti-inflammatory properties are equally significant, inhibiting the release of inflammatory factors and thus reducing inflammatory responses. These properties make ergothioneine bulk powder an ideal ingredient for protecting skin cells and slowing down skin aging.
Application of Ergothioneine in Skin Care
1 Anti-aging
Skin ageing is caused by a number of factors. These include ultraviolet radiation, pollution, and stress. These factors lead to the generation of free radicals, which in turn trigger oxidative stress. Ergothioneine through its powerful antioxidant capacity. It can effectively neutralise free radicals and reduce oxidative damage, thus slowing down the skin ageing process.
2 Moisturising and Repairing
Studies have shown that ergothioneine has a good moisturising effect. It can enhance the hydration of the skin. In addition, ergothioneine can promote skin cell repair and enhance the overall health of the skin.
3 Sun protection and anti-pollution
Ergothioneine can effectively absorb ultraviolet rays. Therefore, ergothioneine bulk powder has a promising application in sunscreen products. In addition, ergothioneine can not only resist environmental pollutants to the skin, but also protect the skin from the damage of external harmful substances.
Experimental data of ergothioneine
1 Antioxidant experimental data
- Free radical scavenging experiments
In one study, scientists scavenged free radicals through DPPH (1,1-diphenyl-2-picrylhydrazyl). This verified the antioxidant capacity of ergothioneine. The results showed that ergothioneine was able to significantly scavenge DPPH free radicals at a low concentration (10 μM). The scavenging efficiency was comparable to that of commonly used antioxidants.
- UV-induced oxidative stress experiment
In another study, researchers used ultraviolet (UVB) light to irradiate human skin fibroblasts. The researchers observed the protective effect of ergothioneine against UVB-induced oxidative stress. It was found that cells pre-treated with ergothioneine showed a significant reduction in reactive oxygen species (ROS) production and a significant increase in cell survival compared to untreated cells. This indicates that ergothioneine bulk powder can effectively reduce UV-induced oxidative stress and protect skin cells from damage.

2. Anti-inflammatory experimental data
- Inflammatory factor inhibition experiment
In an in vitro experiment, scientists used LPS (lipopolysaccharide) to stimulate human skin keratinocytes and induce an inflammatory response
. And different concentrations of ergothioneine were added to the treatment. The results showed that ergothioneine significantly inhibited the secretion of the inflammatory factors TNF-α and IL-6. The inhibition effect was concentration-dependent. This indicates that ergothioneine has significant anti-inflammatory effects.
- UV-Induced Skin Inflammation Experiment
In an in vivo experiment, researchers exposed the skin of mice to UVB radiation to induce skin inflammation. A cream containing ergothioneine was also applied. The results found that skin inflammation was significantly reduced in mice treated with ergothioneine. Erythema and inflammatory cell infiltration were significantly reduced. This indicates that ergothioneine can effectively reduce UV-induced skin inflammation.
3 Moisturising and repair experimental data
- Skin moisturising experiment
In a clinical experiment, researchers applied a lotion containing ergothioneine to the skin of volunteers. It was used continuously for 4 weeks. The results showed that the moisture content of the skin with the ergothioneine-containing lotion was significantly increased. The hydration of the skin was significantly enhanced. The volunteers' skin felt softer and smoother. This indicates that ergothioneine has a good moisturising effect.
- Skin Barrier Function Experiment
In an in vitro experiment, scientists exposed human skin keratin-forming cells to harmful substances. The protective effect of ergothioneine bulk powder on skin barrier function was observed. It was found that ergothioneine was able to significantly reduce the damage to the skin barrier function caused by harmful substances,. In addition, l ergothioneine supplement was able to promote the repair and regeneration of skin cells and improve skin texture.
4 Other related experimental data
- Cell Survival Rate Experiment
In one study, researchers treated human skin fibroblasts with H2O2 (hydrogen peroxide) to induce oxidative damage to the cells, and added different concentrations of ergothioneine to the treatment. The results showed that l ergothioneine mushrooms was able to significantly increase cell survival and attenuate H2O2-induced apoptosis. This suggests that ergothioneine health benefits has a protective effect on skin cells.
- Skin elasticity experiment
In a clinical trial, researchers applied ergothioneine-containing skin care products to the skin of volunteers for 8 weeks to observe its effect on skin elasticity. The results showed that skin elasticity was significantly improved and the skin was firmer with the use of ergothioneine-containing skin care products. This suggests that ergothioneine has the effect of improving skin elasticity and contributes to anti-aging.
Prospects for Ergothioneine in the Cosmetics Market
1. Market Demand Analysis
As people's attention to health and beauty is increasing, the application of natural ingredients in cosmetics is becoming more and more widespread. As a natural antioxidant and anti-inflammatory ingredient, ergothioneine bulk powder meets the current market demand for natural, safe and effective ingredients. Especially in the field of high-end skin care products such as anti-aging, sun protection and skin repair. Ergothioneine bulk powder has a broad application prospect.
2. Product development and application
At present, some skin care products containing ergothioneine have appeared on the market. Such as creams, serums and sunscreens. These products are added with l ergothioneine powder. This enhances the antioxidant, anti-inflammatory and moisturising properties of the products. As a result, these products have become popular among consumers.
With the increased concern for skin health, the application of mushroom ergothioneine in the cosmetic industry is promising. In the future, the application of ergothioneine bulk powder in cosmetics will become more and more widespread with the advancement of technology and market expansion. If you are interested in ergothioneine price, welcome to enquiry us:info@gybiotech.com.






