Apigenin 98%

Natural Apigenin 98% Powder | Bulk Nutraceutical Ingredient

Guanjie Biotech supplies high-quality Apigenin 98% Powder, a light-yellow, high-purity nutraceutical ingredient with competitive pricing. Apigenin 98% is almost insoluble in water, partially soluble in hot alcohol, and soluble in dilute KOH solution. As a professional Apigenin powder supplier and manufacturer, Guanjie Biotech applies strict quality control throughout production. We provide in-house HPLC testing reports and third-party documentation for quality verification. With two production lines, our annual Apigenin 98% production capacity reaches approximately 20 tons, serving more than 50 customers worldwide.

Why Choose Guanjie Biotech?

● GMP standard workshop and two independent laboratories, which ensure quality control and product purity.

● We have two independent laboratories, which allow for testing and analysis of our products to ensure that they meet purity and effectiveness.

● Have strong Collaborators: Northwestern University and the Chinese Academy of Sciences research center.

● Strict quality control system: Almost all the testing items of products are tested in-house.The assay, water, odor, heavy metals, solvent residue, pesticide residue, Protein, Microbiological, and so on.

● Professional shipping: Professional shipping agents have cooperated with us for over 20 years, ensuring that the goods can be exported safely and quickly.

 

What Is Apigenin?

Apigenin 98% is a high-purity flavonoid powder naturally found in various plants. As a plant-derived polyphenolic compound, Apigenin is recognized for its antioxidant properties and ability to help scavenge free radicals. 98% Apigenin powder is commonly used as a functional ingredient in dietary supplements, nutraceutical formulations, and botanical products. Its high purity and standardized composition make it suitable for manufacturers seeking consistent raw materials. As a natural flavonoid, Apigenin is associated with plant defense and protection against environmental stressors such as solar radiation and pathogens.

 

Apigenin COA (Certificate of Analysis)

ITEM	SPECIFICATION	RESULT
Description
Appearance	Light-yellow Powder	Complies
Odor	Characteristic	Complies
Taste	Characteristic	Complies
Extract Solvents	Water and Ethanol	Complies
Particle Size	100% pass through 80 mesh sieve	Complies
Tests
Loss on Drying (5h at 105°C)	< 2%	0.67%
Ash (3h at 600°C)	< 2%	0.45%
Total Heavy Metals	< 20ppm	Complies
Lead	< 2ppm	Complies
Arsenic	< 2ppm	Complies
Assay (by HPLC)
Apigenin	98%	98.16%
Microbial
Total Bacterial Count	Max. 1000cfu/g	Complies
Yeast & Mould	Max. 100cfu/g	Complies
Escherichia coli	Negative	Complies
Salmonella	Negative	Complies
Storage	Store in a cool & dry place. Store in well-closed containers.
Conclusion	Conforms to specification.

 

 

Manufacturing Process & Production Flowchart for Apigenin 98%

Shaanxi Guanjie Biotech Technology Co., Ltd. utilizes a standardized, cGMP-compliant manufacturing process to produce high-purity Apigenin 98% powder (CAS 520-36-5). Each batch follows a strictly controlled 6-stage extraction and purification workflow designed to maximize active bioflavonoid yields while preserving heat-sensitive plant compounds.

 

Step-by-Step Production Workflow

● Solvent Extraction:

Raw botanical biomass (Matricaria chamomilla or celery) undergoes low-temperature, food-grade solvent extraction in stainless steel reactors to isolate raw bioflavonoid intermediates without chemical degradation.

● Vacuum Concentration:

The liquid extract is transferred to low-pressure vacuum evaporators to reduce moisture content, recover active solvents, and increase crude extract concentration under precise thermal controls.

● Column Purification:

Concentrated liquid passes through industrial column chromatography to separate target Apigenin molecules from extraneous plant lipids, chlorophyll, and inactive botanical fractions, achieving a baseline active purity of ≥98.0%.

● Spray & Vacuum Drying:

Purified liquid Apigenin is processed through rapid spray-drying and vacuum desiccators to yield a uniform, dry active pharmaceutical ingredient (API) powder with minimal moisture content (≤2.0%).

● Smashing & Blending:

Dry raw active material is micronized to an exact 80-mesh powder consistency and transferred to stainless steel V-blenders to guarantee batch-to-batch homogeneity, bulk density consistency, and smooth dissolution properties.

● Packaging & Warehousing:

Finished bulk Apigenin 98% is sealed in double-lined, food-grade polyethylene bags inside 25kg fiber drums, vacuum-sealed for stability, and stored in climate-controlled cleanroom warehouses before quality control release and global distribution.

 

Quality Assurance & Technical Parameters

Stage Identifier	Primary Equipment	Core Quality Metric
Extraction & Concentration	Stainless Steel Reaction Tanks	Low-temperature preservation of flavone structures
Purification	Industrial Resin Chromatography Columns	Assay purity ≥ 98.0% confirmed via HPLC
Drying & Pulverization	Vacuum Spray Dryers & 80-Mesh Pulverizers	Loss on Drying ≤2.0%; particle size uniformity
Final Packaging	100,000-Class Cleanroom Facilities	Zero microbiological contamination; tamper-evident sealing

 

Apigenin Specifications:

● Appearance: Fine, light yellow powder
● Solubility:

It is slightly soluble in water, soluble in alcoholic solvents such as ethanol and methanol, and insoluble in non-polar solvents such as hexane and chloroform.
● Purity:

Guanjie's Apigenin 98 powder has a purity of 98% or higher. We can also support customized products.
● Shelf life:

When stored properly in a cool, dry place, it has a shelf life of approximately two years.

 

Advanced Extraction and Purification

At Shaanxi Guanjie Biotech, our production systems strictly follow Good Manufacturing Practices (GMP). Our Apigenin 98.0% production process combines controlled-temperature enzymatic hydrolysis, non-toxic solvent extraction, and multiple recrystallization steps. This integrated approach is designed to achieve consistent high purity while avoiding destructive chemical modification.

As a professional bulk apigenin 98.0% manufacturer and Apigenin powder supplier, we focus on process consistency, purity, and quality control. The resulting 98% Apigenin powder is suitable for customers seeking a high-purity Apigenin raw material for further formulation and product development.

In-House Analytical Testing and Quality Assurance

Every commercial batch of Guanjie Biotech's Apigenin 98% undergoes multi-tiered laboratory testing before release. A Certificate of Analysis (COA) is generated for each lot to verify the product's active content, safety, and chemical integrity. This comprehensive Apigenin quality control system helps provide reliable specifications for bulk ingredient procurement.

HPLC Analysis

High-Performance Liquid Chromatography (HPLC) is used for accurate quantification of Apigenin active content. This testing helps confirm the specified purity and identify potential peak interference or adulteration, providing important analytical support for 98.0% Apigenin powder quality assessment.

Heavy Metals Testing

Heavy metals are tested using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The specified limits are:

• Total heavy metals: <10 ppm
• Lead: <2 ppm
• Arsenic: <1 ppm
• Cadmium: <1 ppm
• Mercury: <0.1 ppm

These controls help verify the suitability and consistency of the high-purity Apigenin raw material.

Pesticide Residue Testing

The product is screened against European Pharmacopoeia (EP) and USP multi-residue standards, covering more than 400 pesticide screens. This testing provides additional quality assurance for customers sourcing bulk Apigenin powder.

Residual Solvent Testing

Residual solvents are controlled according to ICH Q3C guidelines. The specified limits include ethanol below 5,000 ppm, while methanol and benzene are absent according to the stated specification.

Microbiological Testing

Microbiological quality is also controlled for every commercial batch. The specifications include a Total Plate Count below 1,000 CFU/g and Yeast & Mold below 100 CFU/g, with negative results for E. coli, Salmonella, Staphylococcus aureus, and Pseudomonas aeruginosa.

Through controlled extraction, purification, and analytical testing, Guanjie Biotech provides 98% Apigenin with documented quality parameters and batch-level COAs to support professional ingredient sourcing.

 

What Is Apigenin Used For?

Apigenin 98.0% is a high-purity flavonoid ingredient increasingly used by supplement formulators and nutraceutical manufacturers. As a natural Apigenin source, Apigenin powder is studied for its interactions with multiple biological pathways, including GABAergic signaling, cellular NAD+ metabolism, inflammatory responses, oxidative stress, and neuronal function. These properties make bulk Apigenin 98% a valuable ingredient for developing targeted health and wellness formulations.

GABAergic Modulation and Sleep Support

Apigenin has been studied for its interaction with the GABAergic system, including binding to sites associated with the central benzodiazepine receptor on the GABA_A receptor complex. Through this mechanism, Apigenin may contribute to calming and relaxation effects and has therefore attracted interest in sleep-support formulations. Compared with conventional synthetic sedatives, Apigenin powder is being investigated as a botanical-derived ingredient for products focused on relaxation and healthy sleep. However, its effects and mechanisms should not be interpreted as equivalent to prescription sedatives.

Cellular Longevity and CD38 Research

One important area of current research is the relationship between Apigenin and CD38. CD38 is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular energy metabolism and several biological processes. Experimental research suggests that Apigenin may inhibit CD38 activity, potentially helping preserve cellular NAD+ availability. This mechanism has generated interest in Apigenin 98% for healthy-aging and longevity-oriented supplement research, although further human research is needed to establish its clinical significance.

Anti-Inflammatory and Antioxidant Activity

Apigenin has also been extensively investigated for its antioxidant and anti-inflammatory properties. Research indicates that it can modulate signaling pathways associated with Nuclear Factor Kappa B (NF-κB), a transcription factor involved in inflammatory responses. Apigenin may also influence inflammatory mediators, including TNF-α, IL-6, and IL-1β, as well as enzymes such as COX-2 and iNOS.

At the same time, Apigenin's antioxidant activity may help regulate reactive oxygen species (ROS) and support endogenous antioxidant defenses. These characteristics make high-purity Apigenin relevant to nutraceutical formulations targeting oxidative stress and healthy cellular function.

Neuroprotection and Cognitive Research

Apigenin is additionally being studied for its potential neuroprotective effects. Experimental research suggests that Apigenin may interact with pathways related to oxidative stress, neuronal signaling, neurite development, and synaptic plasticity. These findings have encouraged interest in Apigenin for supplements designed around cognitive wellness, focus, and long-term brain health.

 

Comprehensive B2B OEM / ODM Custom Services

Shaanxi Guanjie Biotech provides comprehensive Apigenin 98.0% OEM and ODM services for brands, supplement manufacturers, and distributors seeking reliable bulk Apigenin powder solutions. From ingredient selection and formulation development to dosage form production and private labeling, our services can be customized to meet different market and product requirements.

Hard Capsule OEM:

We offer customized Apigenin capsules in Size 0 and Size 00, with a choice of vegetarian HPMC or gelatin shells. Customers can also specify capsule colors, fill weights, and formulation requirements. Apigenin 98% powder can be formulated at customized fill levels from 100 mg to 500 mg per capsule.

Tablet Compression:

Our Apigenin supplement OEM service supports standard round, oval, and chewable tablets. Custom film or enteric coatings can be developed to meet formulation and product requirements, helping to improve handling, stability, and consumer convenience.

Softgel ODM:

For customers seeking advanced delivery formats, we provide customized softgel solutions using oil-suspended Apigenin formulations. Liposomal or specialized delivery systems can also be evaluated based on formulation objectives.

Custom Premixes & Blends:

We develop homogeneous Apigenin powder blends combining Apigenin with selected vitamins, minerals, and botanical extracts. These Apigenin custom formulations support private-label supplement development and differentiated product concepts.

 

FAQs:

Q1: Why is 98.0% HPLC purity important for B2B supplement manufacturers?

A: A 98.0% HPLC purity grade ensures precise batch-to-batch dosing, low heavy metal content, and consistent active ingredient potency for formulation compliance. Lower purity extracts often contain variable amounts of plant moisture, waxes, and heavy metals that can degrade product shelf-life or alter capsule weight uniformity. Using 98% standardized raw powder allows formulators to meet strict international regulatory standards, such as U.S. FDA cGMP, European EFSA, and ISO compliance.

Q2: How should bulk Apigenin 98.0% powder be formulated for optimal bioavailability?

A: Because raw Apigenin 98.0% is hydrophobic and has limited solubility in water, it is best formulated alongside healthy fats, liposomal delivery systems, or synergistic bio-enhancers. Common commercial formulations combine bulk Apigenin with L-Theanine, Magnesium Glycinate, or Piperine (black pepper extract) to enhance systemic absorption. For liquid or beverage applications, instantized or micronized powder grades are recommended.

Q3: What quality control tests are required for verified Apigenin 98.0% raw materials?

A: Verified Apigenin 98.0% requires a complete Certificate of Analysis (COA) detailing HPLC assay verification, heavy metal screening, solvent residue limits, pesticide screening, and microbiological testing. Critical standard thresholds include Lead (≤0.5 ppm), Arsenic (≤2.0 ppm), Total Plate Count (<1,000 CFU/g), and negative results for pathogens like E. coli and Salmonella.

Q6: What is the recommended dosage for Apigenin 98.0% in finished dietary supplements?

A: The standard clinical dosage for finished consumer products ranges between 50 mg and 200 mg per day, typically taken 30 to 60 minutes before bedtime. Because 98.0% is an industrial active pharmaceutical/nutraceutical grade ingredient, bulk formulators adjust the raw filling mass based on target capsule capacities and bio-enhancer ratios.

Q4: How does Apigenin 98.0% compare to Chamomile Extract 1.2%?

A: Apigenin 98.0% is an isolated, high-potency compound, whereas Chamomile Extract 1.2% is a crude botanical extract containing broad plant constituents. Requiring significantly less capsule volume, 98.0% Apigenin is ideal for targeted single-active or high-strength stack formulas, while 1.2% extract is better suited for traditional tea blends or multi-herb soothing products.

Q5: What manufacturing certifications should a reliable Apigenin 98.0% supplier hold?

A: A qualified global supplier should hold cGMP (Good Manufacturing Practice) certification alongside ISO 22000, HACCP, Halal, and Kosher certifications. These certifications ensure that the production facilities operate under cleanroom conditions, implement strict batch-traceability protocols, and comply with international food and dietary supplement safety regulations.

Q6: What are the proper storage conditions and shelf life for bulk Apigenin 98.0%?

A: Bulk Apigenin 98.0% has a standard shelf life of 24 months when stored in sealed, light-resistant containers under cool, dry conditions below 25°C (77°F). Exposure to direct heat, ambient humidity, or direct UV light can lead to degradation or moisture absorption, compromising the powder's flowability and assay percentage over time.

Factory&Team：

 

Certification

 

Package & Shipment

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