Pure Luteolin Powder

Pure Luteolin Powder Supplier:

Guanjie Biotech focuses on luteolin bulk powder researching, producing and sale. We have our own two factories. They cover an area of 7000㎡, including GMP standard workshop of 2000㎡. All of which are fully compliant with good manufacturing policies and follow the strictest quality controls. We can provide you with high quality products at the best price.

 

Pure luteolin powder is widely distributed in nature, because it was originally isolated from the leaves, stems and branches of ResedaodorataL., a herbaceous plant belonging to Resedaceae, and it is named after it. It can be isolated from a variety of natural medicinal materials and vegetable fruits. It is mainly found in natural medicinal materials such as honeysuckle, chrysanthemum, schizopeta, White prunella, artichoke, Perilla, Scutellaria, naked purple pearl, and in vegetable fruits such as Brussels sprouts, cabbage, cauliflower, beet, broccoli, carrot, celery, bell pepper, pepper and groundnut. It is also found in other plant products such as olive oil and red wine, as well as in wild impatiens, thyme herb, and the labiaceae plant Heliotrope and musculus. At present, luteolin powder on the market is mostly hydrolyzed from rutin, which is the source of Sophorae bud.

 

COA

Item	Specification	Result	Method
Basic Product Information
Genus and Species	Sophora japonica L.	Conform	/
Part of the Plant	Bud	Conform	/
Country of Origin	China	Conform	/
Marker Compounds
Assay(Luteolin )	98%	98.75%	HPLC
Organoleptic Data
Appearance	Powder	Conform	GJ-QCS-1008
Color	Yellow-green	Conform	GB/T 5492-2008
Odor	Characteristic	Conform	GB/T 5492-2008
Taste	Characteristic	Conform	GB/T 5492-2008
Process Data
Method of Processing	Extraction	Conform	/
Solvent(s) Used	Ethanol and Water	Conform	/
Excipient	None	Conform	/
Drying Method	Vacuum drying	Conform	/
Physical Characteristics
Particle Size (80 mesh)	98.0%pass 80mesh	Conform	GB/T 5507-2008
Moisture	<5%	0.26%	GB/T 14769-1993
Ash Content	<5%	1.53%	AOAC 942.05, 18th
Solvent Residue	Eur Pharm	Conform	GJ-QCS-1007
Heavy Metals
Total Heavy Metals	<10 ppm	Conform	USP<231>, method II
Arsenic	<1.0 ppm	0.25ppm	AOAC 986.15, 18th
Lead	<1.0 ppm	0.30ppm	AOAC 986.15, 18th
Mercury	<0.5 ppm	0.26ppm	AOAC 971.21, 18th
Pesticide Residue
666	<0.2ppm	Conform	GB/T5009.19-1996
DDT	<0.2ppm	Conform	GB/T5009.19-1996
Microbiology
Total Plate Count	<1,000cfu/g	160cfu/g	AOAC 990.12, 18th
Total Yeast & Mold	<100cfu/g	10cfu/g	FDA (BAM) Chapter 18, 8th Ed.
E. Coli	Negative	Negative	AOAC 997.11, 18th
Salmonella	Negative	Negative	FDA (BAM) Chapter 5, 8th Ed.

 

Test Method:

 

 

Physical properties:

Pure Luteolin Powder is yellow needlelike crystals, melting point 328~330℃. Slightly soluble in water, weakly acidic, soluble in alkaline solution, stable under normal conditions.

 

Solubility:

Pure luteolin powder is isolated from ethanol as a golden spicule containing a water of crystal. Soluble in ethanol, ether; Slightly soluble in hot water, poorly soluble in cold water. Aqueous solution is a pleasant light yellow, soluble in 10% sodium hydroxide aqueous solution, and a deep yellow. Dissolve in concentrated sulfuric acid to produce zinc salt, dark red yellow.

 

How does it work?

Pure Luteolin Powder is a natural flavonoid found in many plants. Pure Luteolin Powder has a variety of pharmacological activities, such as anti-inflammatory, anti-allergy, lowering uric acid, anti-tumor, antibacterial, antiviral, etc. It is mainly used in clinical cough, expectorant, antiinflammatory, lowering uric acid, the treatment of cardiovascular diseases, the treatment of amyotrophic lateral sclerosis, SARS, hepatitis and so on.

 

Pure Luteolin Powder mostly in the form of glycoside exists in a variety of plants, these plants in the whole leaf blue orchid, pepper, wild chrysanthemum, honeysuckle, Perilla high content. It has antitussive and expectorant effects. According to the latest research, respiratory symptoms cough, expectoration, wheezing, and chronic airway inflammation. Such as bronchial asthma, chronic obstructive pulmonary disease, chronic pharyngitis, allergic rhinitis and other causes of cough, expectoration, wheezing, are considered to be related to local inflammatory infiltration, the existence of inflammation causes the airway immune response chaos, and patients often appear airway responsiveness. Treatment should first eliminate chronic inflammatory infiltration of the airways.

Glucocorticoids are commonly used to reduce airway inflammation. However, glucocorticoid has more side effects and should not be used for a long time. Studies have shown that Pure Luteolin Powder inhibits the phosphorylation of macrophages, inhibits the activity of transcription factor NFKB, and inhibits the production of cytokines IL6 and TNFA in LPS induced macrophages. In addition, it can inhibit the formation of uric acid and promote the excretion of uric acid. The latter two cytokines play a very important role in the mechanism of inflammation and are sensitive indicators reflecting the degree of inflammation. It can also increase IFNγ, decrease specific IGE, and reduce eosinophil infiltration. In addition, it not only has anti-inflammatory and anti-allergic effects, but also has anti-PDE, anti-SARS and ANTI-HIV properties. The reason is that it inhibits the activity of SARS virus preS protein, thus preventing it from entering host cells. For the treatment of COPD, bronchial asthma, as well as chronic pharyngitis, allergic rhinitis caused by chronic cough.

 

New mechanism

At present, many chemotherapy drugs for the treatment of blood cancer will not only poison cancer cells, but also produce toxicity to normal functioning blood cells, resulting in serious side effects for patients. If we can study and screen out compounds that selectively poison only blood cells, the side effects of blood cancer treatment can be reduced.

Fruits and vegetables in addition to providing nutrients to sustain the health of daily life, also is rich in many have potential preventive care and treatment of diseases of plant element (phytochemicals), and molecular biology from tzu chi university department of human genetics professor YanRuiHong team, and genetic counseling center cell genetic Hualien tzu chi hospital group team cooperation study, Dr Yiyi Angle Pure Luteolin Powder, a dietary phytohormone rich in vegetables and fruits such as celery, green pepper, broccoli, peristhus and orange orange, can selectively kill malignant blood cell, but does not harm normal blood cell. The antiblood cancer properties and mechanism of Pure Luteolin Powder found in this study provide a new perspective for the chemoprophysis and treatment of blood cancer. The research was conducted by a team of researchers from Tzu chi University and Tzu chi Hospital, and was published in the International Journal of Molecular Sciences in April 2018.

 

Professor Yan ruihong's research team found that it selectively targeted at human myeloid leukemia cell lines had a significant toxicity effect, effectively inhibiting the proliferation of blood cancer cells, but it was not very toxic to the differentiated cells with blood cell function and normal peripheral blood. Further study revealed that a large number of carcinogenic proteins were present in malignant myelogenous leukemia cancer cells, but only a very small amount of tumor~transforming gene 1 (PTTG1) protein was present in the blood cells that differentiated into functional cells.

The team found that the higher the expression of PTTG1 protein in blood cancer cells, the more sensitive they were to the toxicity . Therefore, PTTG1 protein was speculated to be a key molecule of luteolin extract powder's selective anti~cancer effect. The team also further identified the possible molecular and anticancer mechanism involved. PTTG1 oncogenic protein is known to be expressed in a large number of different cancer cells. At present, many studies have found that PTTG1 protein is an important molecule involved in the proliferation of cancer cells. The findings of this study, in addition to the further development, a vegetable and fruit phytohormone, as the basis for research on the prevention and treatment of blood cancer, It also provides new research directions for luteolin to be used in the treatment of other cancers.

 

Act as a regulator of skin aging and inflammation

Pure luteolin powder is a class of flavonoids found in flowers, herbs, vegetables and spices. It plays an important role in protecting plants, for example against ultraviolet radiation by partially absorbing UVA and UVB radiation. It can therefore also act as a first line of defense to reduce adverse photobiological effects in the skin. In addition, the antioxidant and anti~inflammatory activities on keratinocytes and fibroblasts as well as several immune cells (e.g., macrophages, mast cells, neutrophils, dendritic cells, and T cells) are described. luteolin powder inhibits pro~inflammatory mediators (e.g., IL1β, IL6, IL8, IL17, IL22, TNF~α, and COX2) and regulates various signaling pathways (e.g., NFκB, JAK- STAT, and TLR signaling pathways).

In this way, Pure Luteolin Powder regulates many inflammatory processes in the skin. This review summarizes in vitro and in vivo studies of luteolin powder in the areas of skin aging and skin cancer, wound healing, and inflammatory skin diseases including psoriasis, contact dermatitis, and atopic dermatitis. In conclusion, Pure luteolin extract powder may be a promising molecule for the development of topical and systemic agents for inflammatory skin diseases.

 

Application:

● Pharmaceutical

● Health care products

● Cosmetics

 

Why choose us?

● We can do the third party test.

● We guarantee the quality is in conformity with the Certificate of Analysis provided by us, if not, we accept 100% exchange, return back and refund.

● We can reply you within one hour for any inquire questions and complaint.

● We can do OEM/ODM, sachet package.

● Our products are certified with ISO 9001-22000, SC, KOSHER, HALAL.

 

Our factory:

There are two factories both in Baoji city and Shangluo City, Guanjie Biotech factories covers an area of 7000㎡, including GMP standard workshop of 2000㎡.

 

Product Qualification

Luteolin powder process is conducted by highly qualified professionals.

 

Testing Center:

Both the production processes of manufacture and the product itself meet all international standards. And if you need our testing report, we can provide you.

 

Certification

We have obtained the NON-GMO by Pony test international group. And we get the certifications about HALAAL,ISO 9001,ISO 22000,Kosher, PAHS,SC and so on.

 

 

Package&Warehouse:

Shipment:

DHL, Sea freight, FEDEX, you can choose.

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