Researcher found that Horse chestnut extract powder has effect on sports injuries. What's the sports injuries and how does horse chestnut powder effect on sport injuries? Sport injuries are all kinds of injuries that occur in the process of sports. Sports injuries on sports participants caused by the impact is very serious, not only affect the improvement of sports performance, shorten the life of the sport, and in serious cases can also make people disabled, death, to bring people extremely bad physiological and psychological impact, preventing the normal development of sports, therefore, targeted prevention and control measures, the incidence of sports injuries and their harm to a minimum.
● Anti-inflammatory, anti-swelling and anti-exudation
Horse chestnut seed extract powder can reduce the swelling of rat paws induced by ovalbumin and dextrose at the initial phase of inflammation, but not at the later phase of inflammation. Since the initial phase of inflammation is characterized by changes in vascular permeability, hesperidin can reduce edema and exudation by decreasing the permeability of capillary walls.
In a clinical trial, 24 female patients with chronic venous insufficiency in Widmer's stage were selected for the study. Patients were placed in a supine position with the lower extremities elevated 10 cm, the ankles were immobilized, and a pressure of 60 mmHg was applied to the thighs for 20 min, and the gastrocnemius muscle volume was measured by volumetric tracing. The experiment was repeated with 100 mg of β-heptaerythroside sodium and placebo orally.
The results showed that the volume of gastrocnemius muscle increased by 2% after placebo treatment, while the volume of gastrocnemius muscle decreased by 22% after β-heptaerythroside sodium treatment (P=0.006), and the capillary filtration coefficient decreased significantly after 3 h of β-heptaerythroside sodium treatment.
In another experiment in rats, oral administration of Hepatica europaea extract (HCE) 50mg/kg400mg/kg reduced histamine and 5-hydroxytryptamine-induced skin capillary hyperpermeability, and similarly reduced chloroform-induced capillary hyperpermeability in rabbits.
● Enhance vascular tone and contractility, improve microcirculation
Horse chestnut extract powder can promote the selective release of prostaglandin F-2 (PGF-2), increase venous tone, and has the effect of promoting lymphatic reflux, Heptosaponin can also improve the circulation of blood stagnation, accelerate the microcirculation, take away the inflammatory mediators.
In an animal experiment, HCE 25mg50mg perfusion of the saphenous vein in dogs, can enhance the normal venous pressure, and can significantly enhance the normal venous contraction effect of norepinephrine, anesthetized dogs with normal flow rate for jugular-femoral venous perfusion, HCE improve the femoral venous complications and antagonize venous dilation. Intravenous administration of HCE at 2.5 mg/kg and 5 mg/kg significantly enhanced femoral venous pressure and flow rate as well as thoracic lymphatic flow rate, but did not alter various parameters of the arteries. A similar vasoconstrictive effect of heptaoside on arteries was found in a rat aortic ring model study.
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