Melatonin Bulk Powder

Melatonin powder Supplier:

Guanjie Biotech has focused on melatonin bulk powder for many years. Our bulk melatonin powder is a white to off-white crystalline powder with a purity of≥98.0% through an 80 mesh screen. It is slightly soluble in water, soluble in acetone, ethyl acetate, and methanol. Each batch of our products must be tested. High quality and competitive price. Welcome to enquiry us: info@gybiotech.com.

 

COA

RESULT OF ANALYSIS
Item	Standard	Test Method	Result
Appearance	A white to off-white crystalline powdr	Visual observation	Conform
Solubility	Slightly soluble in water,soluble in acetone,ethyl acetate and methanol	USP<1236>	Conform
Identification	IR	USP<197k>	Conform
UV	USP<197u>	Conform
HPLC	USP<621>	Conform
Chloride and sulfate	0.02% MAX	USP<221>	<0.02%
Loss on drying	1.0%MAX	USP<731>	0.09%
Residue on ignition	0.1%MAX	USP<281>	0.04%
Melting range	117-120°C	USP<741>	119.1-119.3°C
Particle size	≥98.0% through 80mesh	USP<429>	Conform
Microorganism	Total Plate Count	1000cfu/g MAX	USP<2021>	<1000cfu/g
Yeasts & Molds	100cfu/g MAX	USP<2021>	100cfu/g
E.Coli	Absent/10g	USP<2022>	Absent/10g
Salmonella	Absent/10g	USP<2022>	Absent/10g
S.aureus	Absent/10g	USP<2022>	Absent/10g
Residual Solvent	Ethanol	500ppm MAX	USP<467>	394ppm
Density	Tap Density	0.45g/ml MIN	USP<616>	0.55g/ml
Bulk Density	0.35g/ml MIN	USP<616>	0.45g/ml
Clarity and degree of opalescence of liquids	Clear in the 1% melatonin solution of ethanol or chloroform	USP<641>	Conform
Heavy metals	Total	10ppm MAX	USP<231>	<10ppm
Pb	1ppm MAX	USP<2232>	<1ppm
As	1ppm MAX	USP<2232>	<1ppm
Hg	0.1ppm MAX	USP<2232>	<0.1ppm
Cd	0.5ppm MAX	USP<2232>	<0.5ppm
Related compounds	Individual impurity	0.1%MAX	USP<621>	0.032%
Total impurity	1.0%MAX	USP<621>	0.17%
Assay(on the dried basis)	98.5%~101.5%	USP<621>	99.86%
Conclusion	Comply with the requirements of USP-NF2021

 

• Regulates circadian rhythms:

Melatonin maintains the body's 24-hour biorhythms by regulating biological clock genes in the suprachiasmatic nucleus (SCN) and peripheral organs throughout the body. such as the sleep-wake cycle. This mechanism ensures that various physiological processes in the body are coordinated and synchronised, contributing to overall health.

 

• Affects the reproductive system:

Melatonin also plays an important role in seasonally breeding animals. Melatonin bulk powder regulats by providing temporal information through changes in melatonin signalling at night. For example, in some seasonally breeding animals, changes in nocturnal melatonin secretion directly affect their reproductive capacity.

 

• Aging and Health:

As we age, melatonin powder bulk decreases. This can lead to disruptions in circadian rhythms, which in turn can negatively impact overall health. This is one of the reasons why older adults are more prone to sleep problems and chronic diseases.

 

 

•Antioxidant Protection

As a powerful antioxidant, melatonin not only plays a role in scavenging free radicals. It also further enhances its antioxidant capacity through a range of metabolites. Melatonin bulk powder has the following antioxidant functions.

 

• Free radical scavenging:

Melatonin is able to react directly with free radicals to form more stable metabolites. Such as cyclic 3-hydroxymelatonin, these metabolites also possess antioxidant activity. This antioxidant cascade allows melatonin to effectively neutralise a wide range of oxidising and nitrogenating free radicals.

 

• Metal Chelation:

Melatonin also chelates transition metals, reducing the production of hydroxyl radicals. Hydroxyl radicals are one of the most destructive free radicals by chelating metal ions. Melatonin effectively reduces the risk of this free radical formation.

 

• Health and Disease Protection

The antioxidant function of melatonin is important in the prevention and treatment of many diseases. Research has shown that melatonin bulk powder has potential in the following areas:

 

• Neurodegenerative diseases:

Melatonin has potential in protecting neurons from oxidative damage. This may help prevent and slow the progression of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

 

• Cancer protection:

Through its antioxidant and anti-inflammatory properties, melatonin may play a role in inhibiting the growth and spread of tumours. In addition, Melatonin bulk powder may enhance the effectiveness of chemotherapy drugs and mitigate their side effects.

 

• Cardiovascular Health:

Melatonin helps reduce the risk of cardiovascular diseases caused by oxidative stress. such as atherosclerosis and hypertension. It maintains the health of the cardiovascular system by protecting vascular endothelial cells and inhibiting inflammatory responses.

• Anti-aging:

As we age, the accumulation of free radicals in the body leads to an increase in oxidative stress. Melatonin helps to slow down the aging process and maintain healthy physiological functions through its powerful antioxidant effects.

 

Because melatonin bulk powder has many functions, future research and applications could be in the following areas:

• Photobiomodulation Therapy:

The use of NIR to promote melatonin production in the skin and other peripheral tissues may play an important role in the prevention and treatment of diseases associated with oxidative stress.

 

• Gene Regulation:

In-depth study of the mechanisms of gene regulation of melatonin synthesis could help develop new therapeutic approaches. Genetic engineering techniques are used to increase the ability to synthesise melatonin in specific cells or tissues, thereby enhancing antioxidant protection.

 

• Antioxidant function of melatonin in plants

In addition to its important role in animals, melatonin bulk powder has antioxidant function in plants. Plant cells also face environmental stresses. Such as high and low temperatures, salinity and drought. All of these conditions lead to the accumulation of reactive oxygen species (ROS), which in turn cause damage to cells. Melatonin, as a potent antioxidant, can help plants resist these unfavourable conditions.

 

• Heat Stress:

Studies have shown that plants increase melatonin synthesis under high temperature conditions. This helps to reduce heat stress-induced ROS levels and protects cell membranes and proteins from oxidative damage.

 

• Cold stress:

Low temperatures similarly induce melatonin synthesis in plants. It reduces the damage to cellular structure by low temperature through antioxidant action and enhances the cold tolerance of plants.

 

• Saline Stress:

High salt concentrations in saline environments lead to osmotic stress and ROS production. Melatonin is able to regulate intracellular osmotic pressure under such conditions while scavenging excess ROS and protecting the normal function of plant cells.

 

• Supplements and Diet:

Studies have shown that melatonin levels in the body can be effectively increased by supplementing with melatonin or consuming melatonin-rich foods. This thereby enhances antioxidant protection and improves health. This is especially important for the elderly and individuals in high oxidative stress environments.

• Drought stress:

Elevated levels of melatonin in plants under drought conditions help to increase the activity of antioxidant enzymes. This reduces drought-induced oxidative damage and enhances plant drought tolerance.

 

• Melatonin in microorganisms

Melatonin is not only found in animals and plants, but is also widely found in microorganisms. This includes bacteria, fungi and algae. Studies on the synthesis and function of microbial melatonin have provided more information on the role of this molecule in the evolutionary process.

 

• Melatonin in prokaryotes:

Research suggests that bulk melatonin powder may have been present in early life forms on Earth and play an antioxidant role in prokaryotes. This function was particularly important in the high oxidative stress environments of early Earth, helping microbes to defend themselves against oxidative stress in their environment.

 

• Melatonin in fungi:

In fungi, melatonin not only has antioxidant functions, but is also involved in regulating growth and developmental processes. For example, in some fungi, melatonin regulates spore formation and mycelial growth, which is important for fungal survival and reproduction.

 

• Melatonin in Algae:

Algae are important primary producers in the aquatic environment. Melatonin plays an equally significant role in algae. It helps algae to maintain normal physiological functions and enhance their adaptive capacity in light-variable and nutrient-poor environments.

 

Melatonin bulk powder has a bright future in clinical medicine because of its many biological effects and multifunctionality.
•Sleep Disorders:

For the treatment of insomnia and other sleep disorders, melatonin has been utilized extensively. Melatonin supplements, a natural sleep regulator, can help balance the biological clock and enhance the quality of sleep. Research has indicated that melatonin has a significant supplementary function in the treatment of cancer. Its antioxidant and anti-inflammatory properties not only boost the effectiveness of radiation and chemotherapy, but also lessen adverse effects associated with the treatment.


• Heart Disease:

Melatonin appears to have potential for both heart disease prevention and therapy. Melatonin assists in lowering the risk of atherosclerosis and hypertension via regulating vascular endothelial function and antioxidant properties.

 

• Neuroprotection:

The neuroprotective properties of bulk melatonin liquid have made it a promising therapy for neurodegenerative illnesses including Parkinson's and Alzheimer's. By lowering inflammation and oxidative stress, it shields neurons from harm and may even delay the course of illness.

 

• Immunomodulation:

The function of melatonin in the immune system is similarly significant. Melatonin bulk powder boosts the body's resilience to infection and controls the immune system, according to studies. Simultaneously, it inhibits autoimmune illnesses and lessens hyperactive immune reactions.

 

• Mechanistic Research:

Extensive research on the production and mode of action of melatonin in many biological systems can provide light on the compound's multifunctionality and the molecular underpinnings of its diverse biological effects. More experimental evidence is specifically required to validate the mechanism of peripheral tissue control of wholesale melatonin powder production.

• Clinical Uses:
Even though melatonin bulk powder has shown promise in clinical settings, more extensive randomised controlled studies are required to confirm its effectiveness and safety. In particular, further research is still needed to discover the best way to use and dose melatonin in various illness situations.

 

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