Dihydroberberine Powder

Dihydroberberine Powder Supplier

Guanjie Biotech is a high-quality dihydroberberine powder supplier, serving global nutraceutical, dietary supplement, and functional food manufacturers. Our dihydroberberine powder is produced under strict quality management systems to ensure consistency, safety, and performance in commercial formulations. It appears as a yellow powder with an assay of≥98%. The particle size is 95% passing through a 30-mesh sieve, which supports uniform blending and stable processing in capsules, tablets, and powder blends. Guanjie Biotech has a stable supply, technical support, and competitive pricing, making us a trusted long-term partner for bulk dihydroberberine sourcing. Welcome to enquire with us at info@gybiotech.com.

 

COA:

Item	Specification	Result	Test Method
Assay	≥98%	99.55%	HPLC
Appearance	Yellow Powder	Conforms	Visual
Odor	Characteristic	Conforms	Organoleptic
Particle size	95% passed 30 mesh	Conforms	30 mesh screen
Water Content	≤1.00%	0.19%	GB 5009.3
Ash	≤1.00%	0.04%	GB 5009.4
Heavy Metals	≤10mg/kg	<10mg/kg	GB 5009.74
Arsenic, As	≤2mg/kg	0.197mg/kg	GB 5009.11
Lead, Pb	≤2mg/kg	0.08mg/kg	GB 5009.12
Mercury, Hg	≤1mg/kg	ND	GB 5009.17
Cadmium, Cd	≤1mg/kg	0.025mg/kg	GB 5009.15
Total Plate Count	≤1000CFU/g	<10CFU/g	GB 4789.2
Total Yeast & Mold	≤100CFU/g	<10CFU/g	GB 4789.15
Coliforms	≤10CFU/g	<10CFU/g	GB 4789.3
Storage	Cold, Drying, Avoid the Sunlight
Shelf life	Two Years
Packing	Pack in paper-drums and two plastic-bags inside. Net Weight: 25kgs/drums.

What Are The Features Of Berberine?

Molecular Structure and Composition
Dihydroberberine (DHB) is a hydrogenated derivative of berberine, belonging to the isoquinoline alkaloid family. Its molecular formula is C20H19NO4, and it has a molecular weight of approximately 341.37 g/mol. Structurally, dihydroberberine differs from berberine in that it contains a reduced double bond in the isoquinoline ring system, giving it a dihydro form. This hydrogenation slightly alters the electronic distribution in the molecule, improving its lipophilicity and enhancing its biological activity compared to berberine. The molecule features multiple aromatic rings, a quaternary ammonium center, and methoxy substituents, which contribute to its stability and interaction with biological targets.

Solubility and Lipophilicity
Unlike berberine, dihydroberberine exhibits significantly higher lipid solubility due to the reduction of the quaternary structure. This increased lipophilicity allows it to cross lipid membranes more efficiently, improving absorption in the gastrointestinal tract. DHB is slightly soluble in water but shows better solubility in organic solvents such as ethanol and methanol, reflecting its amphiphilic nature. These solubility characteristics make DHB a favorable candidate for oral supplementation and pharmaceutical formulations.

Chemical Stability and Reactivity
Dihydroberberine is chemically more reactive than berberine due to the reduced isoquinoline ring. The hydrogenation makes it more prone to oxidation, and it can revert to berberine under certain conditions, such as exposure to air or light. This reversible oxidation-reduction behavior is important for its pharmacological activity, as it acts as a prodrug, converting into berberine in vivo while maintaining higher bioavailability.

 

How Is Dihydroberberine Produced?

As a professional dihydroberberine powder supplier, Guanjie Biotech emphasizes process standardization, quality consistency, and supply reliability. Our structured production workflow allows us to support customers in the dietary supplement, nutraceutical, and functional ingredient markets with a stable, high-quality dihydroberberine product suitable for global distribution.

Raw Material Preparation: Berberine HCl

The production process begins with berberine hydrochloride (Berberine HCl) as the core raw material. Berberine HCl is selected based on defined purity specifications and is subject to an incoming quality inspection, which includes identity confirmation and impurity profiling. High-quality dihydroberberine powder raw material is essential, as it directly affects reaction efficiency and final product stability.

Controlled Reaction (Hydrogenation Process)

Berberine HCl is introduced into a reaction mixture, where it undergoes a controlled chemical reduction process. This step converts berberine into dihydroberberine, a more lipophilic and readily absorbable form. Reaction parameters such as solvent system, temperature, reaction time, and catalysts (where applicable) are carefully optimized and monitored to ensure high conversion rates while minimizing by-products. Process control at this stage is critical for batch-to-batch consistency.

Extraction and Washing

After completion of the reaction, the mixture proceeds to the extraction stage, where the target compound is separated from reaction residues and spent reagents. Suitable extraction solvents are used to isolate dihydroberberine selectively.

This is followed by washing with purified water, a key purification step designed to remove water-soluble impurities, residual salts, and unwanted reaction intermediates. Multiple washing cycles may be applied depending on impurity profiles and internal quality standards.

Liquid Separation

Once washing is completed, the system undergoes liquid separation. This step ensures effective phase separation between organic and aqueous layers, allowing precise recovery of the dihydroberberine-containing phase. Efficient liquid separation improves product purity and supports downstream processing efficiency.

Concentration

The separated solution is then subjected to concentration, typically through reduced-pressure evaporation. This step removes excess solvents while preventing thermal degradation of the active compound. Concentration increases solid content and prepares the material for final solid-state processing.

Drying

Following concentration, the material is transferred to the drying stage, where residual solvents and moisture are removed under controlled conditions. Drying parameters are carefully managed to achieve targeted moisture levels while preserving chemical integrity. The result is a stable, solid form of dihydroberberine powder suitable for milling and formulation.

Sieving and Particle Size Control

The dried dihydroberberine powder product is milled and passed through sieving to obtain uniform particle size distribution. Particle size control is important for downstream applications, including capsule filling, tablet compression, and blending with other functional ingredients. Consistent granularity also improves flowability and handling during packaging.

Quality Control (QC)

Before release, each batch undergoes comprehensive quality control (QC) testing. Typical analyses include identification, assay (content determination), impurity limits, moisture content, and, where required, microbiological testing. This step ensures that dihydroberberine powder meets predefined specifications and customer requirements.

Packing and Final Release

After passing QC, the dihydroberberine powder product proceeds to packing. Guanjie Biotech uses appropriate packaging materials to protect the product from moisture, light, and contamination during storage and transportation. Each package is labeled with batch information to ensure full traceability.

 

What Forms Does Dihydroberberine Have?

Dihydroberberine is commercially available in multiple dosage forms, allowing flexible application across different product categories and consumer preferences.

Capsules and Tablets: Convenient for Daily Use
Capsules and tablets remain the most common and widely accepted delivery forms for dihydroberberine. These formats provide precise dosing, excellent stability, and high consumer compliance. In blood sugar management products, capsules and tablets are especially suitable for daily supplementation routines, such as before or after meals. From a manufacturing perspective, they are easy to standardize, label, and distribute, making them ideal for mass-market nutraceutical brands and professional health supplement lines.

Powder: Versatile for Functional Beverages
Dihydroberberine powder offers greater formulation flexibility and is increasingly popular in functional food and beverage applications. The powder form can be easily mixed into drinks, health beverages, or powdered supplement blends, providing an alternative for consumers who prefer non-pill formats. This makes it suitable for meal-replacement shakes, metabolic drink mixes, or personalized nutrition products. Additionally, powder formulations allow manufacturers to combine dihydroberberine with complementary ingredients such as dietary fiber, plant extracts, or probiotics to create differentiated products in the wellness market.

 

Is Dihydroberberine Safe?

Regarding safety, current research and animal studies indicate that dihydroberberine powder is generally well-tolerated when used at recommended doses. It has a lower risk of gastrointestinal side effects compared to berberine, such as nausea, diarrhea, or abdominal discomfort, which are common complaints with berberine supplementation. However, as with all bioactive compounds, individual responses may vary, and long-term safety data in humans remain limited.

DHB may interact with medications that affect blood sugar, blood pressure, or liver metabolism, so individuals on such treatments should consult healthcare professionals before use. Pregnant or breastfeeding women are also advised to avoid DHB due to insufficient safety data.

From a product perspective, sourcing high-purity dihydroberberine powder from reputable suppliers, such as Guanjie Biotech, ensures quality and consistency, reducing potential risks associated with contaminants or inconsistent dosing. Overall, DHB is considered a safe and effective supplement when used responsibly and under proper guidance.

 

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